The effects of Cordyceps Sinensis on Mood and cognition
The risk of cognitive decline and dementia increases with age. Researchers have found a significant increase in the activity of antioxidant enzymes (glutathione peroxidase, superoxidedismutase, catalase), whose activity was decreased by the aging process. The (ultra) structure of the hippocampus, a brain area in which degenerative changes had occurred, increased strongly by supplementation with Cordyceps. The research suggests that Cordyceps sinensis helps keep the brains healthy with age, both structurally and functionally, partly by improving the antioxidant status.
Since fatigue and depression are closely linked, researchers wanted to know if Cordyceps sinensis has an antidepressant effect. They found confirmation of this hypothesis in a widely used animal model for depression (tail suspension test), in which cordyceps extract (obtained by supercritical fluid extraction with CO2) a significant antidepressant effect showed. The researchers found that the antidepressant activity partly based on influencing the adrenergic * and dopaminergic * systems (and not the serotonergic system). According to the “monoamine hypothesis” monoamines * (norepinephrine, dopamine, serotonin) play an important role in the development of depression symptoms.